ETV4-Mediated PD-L1 Upregulation Promotes Immune Evasion and Predicts Poor Immunotherapy Response in Melanoma
Our findings identify ETV4 as a key transcriptional regulator of immune evasion in melanoma by controlling PD-L1 expression. ETV4 may act as a predictive biomarker for immunotherapy outcomes.
Authors
- Tao-Feng Wei
- Tao Zhu (ORCID: https://orcid.org/0000-0002-2921-4067)
- Junjun Xu (ORCID: https://orcid.org/0000-0001-7996-6219)
- Wei He
- Huifang Jiang (ORCID: https://orcid.org/0000-0002-5049-4227)
- Mingdong Yang (ORCID: https://orcid.org/0000-0002-9656-0365)
- Juyan Zheng
- Haibin Dai
Institutions
- Zhejiang Provincial People's Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Published
- 2025-10-24
- DOI
- https://doi.org/10.32604/or.2025.070180
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00