Endothelin-1 Mediates Oxaliplatin Resistance via Activation of YAP Signaling in Colorectal Cancer
The study demonstrates that EDN1 governs oxaliplatin resistance through the β-arr1/YAP axis and provides preclinical evidence for targeting EDN1 to overcome chemoresistance in CRC.
Authors
- Hong Zhang (ORCID: https://orcid.org/0000-0002-0886-9531)
- Siying Zhu (ORCID: https://orcid.org/0000-0001-8499-3190)
- Chang Yin Liang (ORCID: https://orcid.org/0000-0003-2317-1323)
- Yingqi Zhang (ORCID: https://orcid.org/0000-0001-7783-8336)
- Qingjun Li (ORCID: https://orcid.org/0000-0001-5650-795X)
- Jie Huang (ORCID: https://orcid.org/0009-0006-1871-0598)
- Weiling He
- Ranran Yang
- Dan Yuan (ORCID: https://orcid.org/0000-0003-2831-0388)
Institutions
- Sun Yat-sen University (CN)
- Xiamen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.32604/or.2025.064463
- Primary Topic
- Steroid Chemistry and Biochemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00