Combined Dietary Restriction and Chelation Therapy Reduces Manganese Burden in <scp> <i>SLC39A14</i> </scp> ‐Associated Manganism

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Data S1. Supporting Information Data S2. Supporting Figures Data S3. Supporting Tables Video S1. Intermittent involuntary knee and hip flexion is evident, more prominent on the left, with splaying of the toes. Dystonic scissoring is elicited by elevating the left leg. Despite clear antigravity power, purposeful movement is diminished and appears to be incorporated into parakinetic movements. Video S2. Tracheostomy and gastrostomy tube have been required, and evolution of dystonia is evident, with marked phasic components and a hyperkinetic quality. Video S3. Clinical stability was achieved with combined dietary restriction therapy and chelation, coupled with aggressive medication management, deep brain stimulation therapy, and physical and occupational therapy focused on state regulation (Supplemental). Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.