Occlusion site and outcomes in intra-arterial tenecteplase after successful endovascular therapy: a secondary analysis of the ANGEL-TNK trial
IA tenecteplase had a better functional outcome and lower hemorrhage risk in ICA occlusion compared with standard medical management but not in MCA M1/M2. Occlusion site is a critical determinant of response to IA tenecteplase. A pooled analysis of IA tenecteplase stratified by occlusion site strata is warranted.
Authors
- Ligang Song (ORCID: https://orcid.org/0000-0002-6444-4589)
- Zhongrong Miao (ORCID: https://orcid.org/0000-0001-9642-9415)
- Xin Tong (ORCID: https://orcid.org/0000-0002-4893-1299)
- Thanh N. Nguyen (ORCID: https://orcid.org/0000-0002-2810-1685)
- Xiaochuan Huo
- Wenhuo Chen (ORCID: https://orcid.org/0000-0002-7031-8917)
- Huachen Zhang (ORCID: https://orcid.org/0000-0002-4618-0380)
- Dapeng Sun (ORCID: https://orcid.org/0000-0001-6321-5381)
- Gang Luo (ORCID: https://orcid.org/0000-0003-1544-1434)
- Shuo Li (ORCID: https://orcid.org/0000-0003-0300-1298)
- Yiwen Xu
- Xuelei Zhang (ORCID: https://orcid.org/0000-0001-6209-8187)
- Qi Zhou (ORCID: https://orcid.org/0000-0003-1505-9980)
- Xiaoxi Yao
Institutions
- Boston Medical Center (US)
- Fujian Medical University (CN)
- Beijing Tian Tan Hospital (CN)
- Beijing Anzhen Hospital (CN)
- Chenzhou First People's Hospital (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Journal of NeuroInterventional Surgery
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1136/jnis-2025-024129
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00