Characteristics of an antibody profile associated with protection against hepatitis C virus reinfection in a high-risk cohort
We propose broad, potent serum Fc-mediated effector functions and neutralisation and a broad anti-E1E2 antibody epitope specificity as ingredients of HCV-protective immunity towards which vaccination approaches should aim.
Authors
- Kwinten Sliepen (ORCID: https://orcid.org/0000-0003-1414-0648)
- Marit J. van Gils (ORCID: https://orcid.org/0000-0003-3422-8161)
- Sylvie M. Koekkoek
- Anders C. Boyd (ORCID: https://orcid.org/0000-0001-9512-8928)
- Ana Chumbe (ORCID: https://orcid.org/0000-0003-0870-5075)
- Maria Prins (ORCID: https://orcid.org/0000-0003-2967-0289)
- Marloes Grobben (ORCID: https://orcid.org/0000-0002-1559-9592)
- Janke Schinkel (ORCID: https://orcid.org/0000-0002-1112-0644)
- Ian Zon (ORCID: https://orcid.org/0000-0003-4346-0739)
- Suzanne M D van den Aardweg (ORCID: https://orcid.org/0009-0005-9262-7322)
Institutions
- Stichting HIV Monitoring (NL)
- GGD Amsterdam (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Gut
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1136/gutjnl-2025-336302
- Citations
- 1
- Primary Topic
- Hepatitis C virus research
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- Amsterdam University Medical Centers
- ZonMw