Integrating 2D dosimetry and cell survival analysis for predicting local effect in spatially fractionated radiotherapy
We introduce a novel analysis pipeline for 2D localization of colonies and SFRT survival modelling in vitro. Findings suggest that distance to peak dose regions significantly influences local SFRT effects. Incorporating this spatial factor via an MLQ model may enhance understanding and prediction of SFRT-induced survival.
Authors
- Delmon Arous (ORCID: https://orcid.org/0000-0002-7438-3206)
- Nina Frederike Jeppesen Edin (ORCID: https://orcid.org/0000-0002-6995-131X)
- Eirik Malinen (ORCID: https://orcid.org/0000-0002-1308-9871)
- Jacob Larsen Lie
Institutions
- Oslo University Hospital (NO)
- University of Oslo (NO)
Publication Details
- Journal
- Acta Oncologica
- Published
- 2025-10-24
- DOI
- https://doi.org/10.2340/1651-226x.2025.44599
- Primary Topic
- Advanced Radiotherapy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Helse Sør-Øst RHF