The Impact of Bulbar and Upper Motor Neuron Involvement on Oculomotor Movement in Amyotrophic Lateral Sclerosis
The findings highlight the impact of bulbar and UMN involvement on oculomotor dysfunction in ALS, demonstrating distinct patterns across various phenotypes. Although oculomotor metrics show sensitivity to the pathophysiology of ALS, their effectiveness as independent biomarkers needs further validation through longitudinal studies that include larger cohorts, advanced neuroimaging techniques, and multimodal assessments to capture the complex interplay between motor, cognitive, and anatomical changes in this varied disease.
Authors
- Qing Liu (ORCID: https://orcid.org/0000-0003-0196-041X)
- Dongchao Shen (ORCID: https://orcid.org/0000-0003-0804-4764)
- Yuxin Liu (ORCID: https://orcid.org/0000-0002-8632-2910)
- Mingsheng Liu (ORCID: https://orcid.org/0000-0003-3850-360X)
- Liying Cui (ORCID: https://orcid.org/0009-0004-3725-1871)
- Xunzhe Yang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Chinese Academy of Engineering (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/brb3.70906
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Peking Union Medical College Hospital
- Peking Union Medical College