Comparison of the averaged biodistribution and pharmacokinetics between [99mTc]Tc-HYNIC-TOC and [177Lu]Lu-DOTA-TATE in neuroendocrine tumor patients
While [99mTc]Tc-HYNIC-TOC and [177Lu]Lu-DOTA-TATE show similar biodistribution patterns in the liver and spleen, they differ in renal and lesion uptake and clearance kinetics. The ability of [99mTc]Tc-HYNIC-TOC to capture dynamic behavior through multi-time-point imaging may offer improved prediction of [177Lu]Lu-DOTA-TATE absorbed dose.
Authors
- Sara Kurkowska (ORCID: https://orcid.org/0000-0001-5101-8911)
- Hanna Piwowarska-Bilska (ORCID: https://orcid.org/0000-0003-3617-7687)
- Bożena Birkenfeld (ORCID: https://orcid.org/0000-0003-1174-8199)
Institutions
- Spinal Cord Injury BC (CA)
- Pomeranian Medical University (PL)
Publication Details
- Journal
- Nuclear Medicine Review
- Published
- 2025-03-10
- DOI
- https://doi.org/10.5603/nmr.107203
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00