Acquisition of an immunosuppressive microenvironment after anti-CD19 CAR T-cell therapy is associated with T-cell dysfunction and resistance
In conclusion, CAR T-cell-mediated myeloid activation is associated with pathways of immune dysregulation that may antagonize the effects of therapy.
Authors
- Cristina Bugarin (ORCID: https://orcid.org/0000-0002-7401-7097)
- Markus Gabriel Manz (ORCID: https://orcid.org/0000-0002-4676-7931)
- Ramona Bason (ORCID: https://orcid.org/0000-0003-4304-8584)
- Silvia Ferrari (ORCID: https://orcid.org/0000-0002-9917-2843)
- Massimiliano Pagani
- Silvia Nucera (ORCID: https://orcid.org/0000-0001-9489-142X)
- Marco M Sindoni (ORCID: https://orcid.org/0009-0001-0623-9835)
- Raoul J.P. Bonnal (ORCID: https://orcid.org/0000-0002-2123-6536)
- Stefania Galimberti (ORCID: https://orcid.org/0000-0003-1504-7242)
- Cristian Meli
- Chiara F. Magnani (ORCID: https://orcid.org/0000-0003-2474-2159)
- Giuseppe Dastoli
- Andrea Biondi (ORCID: https://orcid.org/0000-0002-6757-6173)
- Federico Lussana (ORCID: https://orcid.org/0000-0002-6510-8616)
- Giulia Risca (ORCID: https://orcid.org/0000-0002-6389-9434)
- Alessandro Rambaldi (ORCID: https://orcid.org/0000-0002-3739-7502)
- Alex Moretti (ORCID: https://orcid.org/0000-0003-3596-825X)
- Chiara Buracchi (ORCID: https://orcid.org/0000-0002-5345-7448)
- Marianna Ponzo (ORCID: https://orcid.org/0000-0002-0003-5524)
- Benedetta Rambaldi (ORCID: https://orcid.org/0000-0002-5246-9471)
- Grazisa Rossetti (ORCID: https://orcid.org/0000-0001-6361-311X)
- Lorenzo Drufuca (ORCID: https://orcid.org/0000-0002-4368-9034)
- Christian Pellegrino (ORCID: https://orcid.org/0000-0001-7898-9988)
- Giuseppe Gaipa (ORCID: https://orcid.org/0000-0002-1006-5946)
Institutions
- University of Milan (IT)
- University Hospital of Zurich (CH)
- Ospedale Papa Giovanni XXIII (IT)
- Azienda Ospedaliera San Gerardo (IT)
- IFOM (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/jitc-2025-011768
- Citations
- 2
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Science Foundation
- Amgen
- Bristol-Myers Squibb
- Pfizer
- Sanofi
- Gilead Sciences
- Incyte
- Omeros Corporation
- Cancer Research UK
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Ministero della Salute
- Astellas Pharma
- Associazione Italiana per la Ricerca sul Cancro
- Helmut Horten Stiftung