Epigenetic suppression of Nrf2–Slc40a1 axis induces ferroptosis and enhances immunotherapy in pancreatic cancer
Our findings establish a PDO-T cell platform for precision immunotherapy screening and identify JIB04 as a promising epigenetic agent that induces ferroptosis and sensitizes PDAC to immune checkpoint blockade. This ferroptosis-based reprogramming provides a potential strategy to overcome resistance and improve clinical outcomes in PDAC.
Authors
- Shiyi Song
- Chi Shen (ORCID: https://orcid.org/0000-0001-5417-1444)
- Yihan Zhao (ORCID: https://orcid.org/0000-0001-6951-4809)
- Shu Zhang (ORCID: https://orcid.org/0000-0003-4571-742X)
- Yao Fu (ORCID: https://orcid.org/0000-0001-9864-1030)
- Dijun Chen (ORCID: https://orcid.org/0000-0002-7456-2511)
- Tianqi Xu (ORCID: https://orcid.org/0009-0003-9086-5357)
- Xinjie Shen (ORCID: https://orcid.org/0000-0003-3011-0967)
- Yanxin Zhuang (ORCID: https://orcid.org/0000-0002-7830-6347)
- Jiajun Zhang (ORCID: https://orcid.org/0000-0002-4117-343X)
- Yin Zhang (ORCID: https://orcid.org/0000-0002-7146-9581)
- Qi Li (ORCID: https://orcid.org/0000-0003-2120-2261)
- Yixuan Zhang (ORCID: https://orcid.org/0000-0001-9781-6281)
- Lei Wang (ORCID: https://orcid.org/0000-0001-5024-0238)
- Shijin Xu
- Ranran Yu
- Xiaoping Zou (ORCID: https://orcid.org/0000-0003-0194-4567)
- Ziying Zhang (ORCID: https://orcid.org/0000-0002-7402-7893)
- Ying Lv (ORCID: https://orcid.org/0000-0003-2058-7534)
- Jiatong Tang
- Jiawei Liang (ORCID: https://orcid.org/0009-0003-5675-6544)
Institutions
- Nanjing Drum Tower Hospital (CN)
- First Affiliated Hospital of Xinxiang Medical University (CN)
- Henan Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/jitc-2025-013269
- Citations
- 5
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 5.23