CPT1A inhibition alleviates plasmacytoid dendritic cell-mediated immune suppression in colon cancer through fatty acid oxidation modulation
These findings elucidate the molecular mechanism of CPT1A-mediated FAO in TA-pDCs and its implications in immune evasion, suggesting a novel therapeutic strategy for colon cancer immunotherapy.
Authors
- Ning Yang (ORCID: https://orcid.org/0000-0001-5121-7208)
- Guoxia Zang
- Zhong Ren (ORCID: https://orcid.org/0000-0003-0848-7354)
- Jingtao Chen (ORCID: https://orcid.org/0000-0002-4720-4225)
- Jing Wu (ORCID: https://orcid.org/0000-0002-9017-8405)
- Yuan Qiao (ORCID: https://orcid.org/0000-0002-1100-634X)
- Qiuyu Wei
- Shan Zhu (ORCID: https://orcid.org/0000-0003-1531-6174)
- Yong‐Jun Liu
- Helei Wang (ORCID: https://orcid.org/0000-0002-7726-929X)
- Liyan Wang
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/jitc-2025-012162
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05