Sensory neuropeptide CGRP and its co-receptor RAMP1 drive tumour cell growth in gastrointestinal cancers
This study reveals novel mechanisms by which the neuropeptide CGRP promotes tumour growth in GI cancers. We expand upon existing knowledge by demonstrating that tumour cells are a source of CGRP, highlighting potential therapeutic targets within the tumour-nerve axis.
Authors
- Pavitha Parathan
- Lisa A. Mielke (ORCID: https://orcid.org/0000-0002-9522-9320)
- Oliver M. Sieber (ORCID: https://orcid.org/0000-0001-9480-0786)
- Liam Neil
- Yang Liao
- Jessica Da Gama Duarte (ORCID: https://orcid.org/0000-0003-4289-5204)
- John M. Mariadason (ORCID: https://orcid.org/0000-0001-9123-7684)
- Tao Tan (ORCID: https://orcid.org/0000-0001-5924-4112)
- Dmitri Mouradov (ORCID: https://orcid.org/0000-0001-8149-816X)
- Isaac M Chiu
- Peter Gibbs (ORCID: https://orcid.org/0000-0003-1423-4484)
- Annalisa L. E. Carli (ORCID: https://orcid.org/0000-0003-0312-1097)
- Kelly Tran (ORCID: https://orcid.org/0009-0006-3318-7280)
- Michael Büchert (ORCID: https://orcid.org/0000-0003-2672-0148)
- Wei Shi (ORCID: https://orcid.org/0000-0003-1182-7735)
- Bhupinder Pal (ORCID: https://orcid.org/0000-0002-3684-4331)
- David S. Williams (ORCID: https://orcid.org/0000-0002-7758-3932)
- Conor J. Kearney (ORCID: https://orcid.org/0000-0002-9891-5078)
- Anne Huber
Institutions
- Harvard University (US)
- The University of Melbourne (AU)
- Walter and Eliza Hall Institute of Medical Research (AU)
- La Trobe University (AU)
- Australian Regenerative Medicine Institute (AU)
- The Alfred Hospital (AU)
- Monash Alfred Psychiatry Research centre (AU)
- Olivia Newton-John Cancer Wellness & Research Centre (AU)
- Austin Health (AU)
- Monash University (AU)
Publication Details
- Journal
- BMJ Oncology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/bmjonc-2025-000842
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 0.00