Extreme Genetic Diversity and Signatures of Balancing Selection in <i>Plasmodium vivax</i> Blood-Stage Antigens
AMA1, CyRPA, RBP1a, and P41 are under strong immune selection, while other antigens show limited diversity. Current vaccine formulations based on Sal-1 may have limited efficacy. Our results provide a framework for vaccine developers to select more common variants.
Authors
- Alison Paolo N. Bareng (ORCID: https://orcid.org/0009-0002-5456-0313)
- Shannon Takala‐Harrison (ORCID: https://orcid.org/0000-0003-4674-8500)
- Eugenia Martín (ORCID: https://orcid.org/0009-0005-0757-4650)
- Myo Naung (ORCID: https://orcid.org/0000-0001-8595-4310)
- Jacob E. Munro (ORCID: https://orcid.org/0000-0002-2751-0989)
- Alyssa E. Barry (ORCID: https://orcid.org/0000-0002-1189-2310)
- Somya Mehra (ORCID: https://orcid.org/0000-0002-0507-3204)
Institutions
- University of Maryland, Baltimore (US)
- Burnet Institute (AU)
- Deakin University (AU)
- The University of Melbourne (AU)
- Walter and Eliza Hall Institute of Medical Research (AU)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1093/infdis/jiaf539
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00