Cholestane-3β,5α,6β-triol induces cancer cell death by activating GSDME-mediated pyroptosis
CT specifically triggered caspase 3-dependent GSDME cleavage, resulting in pyroptosis as the predominant form of CT-induced cell death. This study establishes a direct mechanistic link between CT and inflammatory cell death execution and provides insight into the contribution of trihydroxysterols to inflammatory pathogenesis.
Authors
- Chuanzhou Li (ORCID: https://orcid.org/0000-0003-0174-4215)
- Zhenyu Cai (ORCID: https://orcid.org/0000-0003-2230-6150)
- Zhuo T. Su (ORCID: https://orcid.org/0000-0003-3215-6192)
- Shui‐Chun Mao (ORCID: https://orcid.org/0000-0002-7569-3011)
- Wen Zhang (ORCID: https://orcid.org/0000-0002-9352-6153)
- Zihan Liu (ORCID: https://orcid.org/0000-0002-3438-7130)
- Yuan He (ORCID: https://orcid.org/0000-0002-6461-5341)
- Hua Han (ORCID: https://orcid.org/0000-0002-7042-5827)
- Jieping Zhang (ORCID: https://orcid.org/0000-0001-5476-0054)
- Yang Chen (ORCID: https://orcid.org/0000-0002-5840-0897)
- Jiaxi Chen (ORCID: https://orcid.org/0000-0003-4363-7282)
- Min Zhao (ORCID: https://orcid.org/0000-0001-7505-9603)
Institutions
- Ningbo University (CN)
- Tongji University (CN)
- Nanchang University (CN)
- Peking University (CN)
- Shanghai Ocean University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-24
- DOI
- https://doi.org/10.3389/fphar.2025.1667156
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00