Transcription factor 25 modulates gametocytogenesis and ribosome biogenesis in the malaria parasite Plasmodium falciparum
This study identifies TCF25 as a key regulator of various biological processes in <i>P. falciparum</i>. It is shown that TCF25 plays a crucial role in gametocytogenesis by influencing the <i>ap2-g</i> pathway. Additionally, a novel function of TCF25 in ribosomal biogenesis is uncovered, wherein it directly controls A-type rRNAs expression and ribosomal subunit homeostasis. These discoveries offer fresh perspectives on the molecular mechanisms that oversee transmission and ribosome biogenesis in malaria parasites.
Authors
- Qingfeng Zhang (ORCID: https://orcid.org/0000-0002-8759-9102)
- Jing Wu (ORCID: https://orcid.org/0000-0001-9550-4380)
- Jian-xin Ye
- Fei Wang (ORCID: https://orcid.org/0000-0001-9539-8397)
- Bin Tian
- Bo Li (ORCID: https://orcid.org/0000-0002-8129-3671)
- Zuping Zhang (ORCID: https://orcid.org/0000-0002-3295-2861)
- Wenyu Yang (ORCID: https://orcid.org/0000-0002-4882-2607)
- Xiaomin Shang
- Peiyi Li
- Chandara Ngim
Institutions
- Central South University (CN)
- Hunan Provincial Center for Disease Control and Prevention (CN)
- Shanghai East Hospital (CN)
- Hunan Provincial People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-10-24
- DOI
- https://doi.org/10.3389/fcimb.2025.1652542
- Citations
- 1
- Primary Topic
- Insect Resistance and Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.81