Quantitative assessment of the usability of electromechanical human-based modelling and simulation to replace Langendorff isolated rabbit heart experiments in the preclinical setting
This study supports the adoption of <i>in silico</i> new approach methodologies for accurate prediction of drug cardiotoxicity, and to refine, reduce and replace the use of <i>ex vivo</i> rabbit experiments.
Authors
- Marcel Mohr (ORCID: https://orcid.org/0000-0001-6553-8651)
- Ambroise Garry
- Véronique Ballet
- Hector Martinez‐Navarro (ORCID: https://orcid.org/0000-0003-0234-2605)
- Blanca Rodríguez (ORCID: https://orcid.org/0000-0001-6361-3339)
- Eva Vermersch (ORCID: https://orcid.org/0000-0003-4813-2355)
- Friedemann Schmidt (ORCID: https://orcid.org/0000-0003-0265-0974)
- Maxx Holmes (ORCID: https://orcid.org/0000-0002-2299-9455)
- Jean‐Marie Chambard
Institutions
- Sanofi (France) (FR)
- University of Oxford (GB)
- Sanofi (Germany) (DE)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-24
- DOI
- https://doi.org/10.3389/fphar.2025.1671199
- Citations
- 1
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Sanofi
- Wellcome Trust
- Sanofi-Aventis Deutschland
- Engineering and Physical Sciences Research Council