Montelukast: risk of mental disorders vs. efficacy–a meta-analysis

In terms of treating asthma and allergic rhinitis, montelukast shows comparable efficacy to other drugs, such as inhaled corticosteroids or second-generation antihistamines. Furthermore, montelukast was associated with a modestly increased risk of anxiety, while no consistent evidence was found for an increased risk of depression or suicidal behaviors, considering the limited data.