Androgen deprivation promotes diabetic wound healing in mice through modulation of wound microbiome and immune response
Low androgen levels were associated with improved diabetic wound repair, potentially by attenuating local inflammation and fostering a more diverse, metabolically active microbiota. These data support a mechanistic link among androgens, wound inflammation, and the microbiome, and suggest host-directed therapeutic strategies for chronic diabetic wounds.
Authors
- Ziyang Sun (ORCID: https://orcid.org/0000-0002-8673-9521)
- Ruoyu Mu (ORCID: https://orcid.org/0000-0002-6093-0176)
- Qian Tan (ORCID: https://orcid.org/0000-0001-7710-7082)
- Huaikai Shi (ORCID: https://orcid.org/0000-0002-8269-2981)
- Xin Yan (ORCID: https://orcid.org/0000-0002-5555-9886)
- Rizhong Huang (ORCID: https://orcid.org/0009-0009-3646-8346)
- Yiwei Wang (ORCID: https://orcid.org/0000-0001-6585-6641)
- Yangyu Song (ORCID: https://orcid.org/0000-0003-2522-9744)
- Jinlong Huang (ORCID: https://orcid.org/0000-0002-4390-6035)
- Zihao Sun (ORCID: https://orcid.org/0009-0000-5915-8871)
- Lixiang Zhang
- Jingyi Chen (ORCID: https://orcid.org/0000-0002-3716-5023)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jiangxi University of Technology (CN)
- Asbestos Diseases Research Institute (AU)
- Nanjing Drum Tower Hospital (CN)
- Carnegie Mellon University (US)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-10-24
- DOI
- https://doi.org/10.3389/fmicb.2025.1684165
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00