PARP inhibition increases sensitivity to cisplatin in non-small-cell lung carcinoma via the induction of TET-dependent hydroxymethylation
The improved response to cisplatin following PARPi-mediated sensitization of A549 cells, accompanied by the restoration of 5hmC levels, provides additional insights into the epigenetic mechanisms underlying the synergy between PARPi and cisplatin. The use of PARPi in clinical settings could increase the number of patients enriched in 5hmC, who might benefit from platinum-based therapy. Additionally, targeting epigenetic marks could provide a molecular basis for personalized cancer therapy directed to overcome tumor resistance.
Authors
- Jovana Rajić (ORCID: https://orcid.org/0000-0002-2808-8484)
- Marijana Stojanović (ORCID: https://orcid.org/0000-0002-8204-4183)
- Tijana Markovic (ORCID: https://orcid.org/0009-0004-7726-1716)
- Nevena Grdović (ORCID: https://orcid.org/0000-0003-1504-4578)
- Svetlana Dinić (ORCID: https://orcid.org/0000-0002-7612-3117)
- Mirjana Mihailović (ORCID: https://orcid.org/0000-0002-8097-1186)
- Ana Podolski-Renić (ORCID: https://orcid.org/0000-0001-7412-3685)
- Stefan Hadžić (ORCID: https://orcid.org/0000-0001-8459-2776)
- Melita Vidaković (ORCID: https://orcid.org/0000-0001-8410-6264)
- Milica Pešić (ORCID: https://orcid.org/0000-0002-9045-8239)
- Anja Tolić (ORCID: https://orcid.org/0000-0003-4703-6214)
- Aleksandra Uskoković (ORCID: https://orcid.org/0000-0002-9616-1102)
- Mirna Jovanović (ORCID: https://orcid.org/0000-0003-2200-3942)
- Jelena Arambašić Јovanović (ORCID: https://orcid.org/0000-0002-8810-0668)
- Marija Đorđević (ORCID: https://orcid.org/0000-0001-9051-9583)
- Ana Šarić (ORCID: https://orcid.org/0000-0002-6116-9606)
Institutions
- University of Belgrade (RS)
- Institute of Physics Belgrade (RS)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-10-24
- DOI
- https://doi.org/10.3389/fcell.2025.1677261
- Citations
- 1
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.05