Exogenous melatonin boosts vaccine-induced immunity in individuals with high pre-existing influenza immunity
The data suggest that the melatonin has a selective modulatory effect on the antigen-specific cTfh subset response based on the levels of pre-existing HAI antibodies and the previously imprinted immune landscape. Given the disease's complex immune history, melatonin shows promise as a potential adjuvant for seasonal influenza vaccines.
Authors
- Wathsala Wijayalath
- Kyosuke Oda
- Janine Danko (ORCID: https://orcid.org/0000-0002-6095-3212)
- Elke S. Bergmann‐Leitner (ORCID: https://orcid.org/0000-0002-8571-8956)
- Rachel Lee (ORCID: https://orcid.org/0009-0009-5024-0647)
- Eileen Villasante
Institutions
- Henry M. Jackson Foundation (US)
- Naval Medical Research Command (US)
- Uniformed Services University of the Health Sciences (US)
- University of San Diego (US)
- Walter Reed National Military Medical Center (US)
- University of California San Diego (US)
- Walter Reed Army Institute of Research (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1663763
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00