Disseminated Kaposi sarcoma patients exhibit an expanded population of CD8+CD57+ T cells and an immunosenescence profile
The microenvironment generated in DKS/HIV patients increases the frequency of T-cells exhibiting an immunosenescence phenotype, and this effect is independent of the treatment schedule used, suggesting that during coinfection, a chronic immunosuppressive microenvironment may develop, impairing immune surveillance and resilience. These results could be explored to identify novel therapeutic approaches.
Authors
- Lucero A. Ramón‐Luing (ORCID: https://orcid.org/0000-0003-2004-7570)
- Patricia Volkow-Fernández (ORCID: https://orcid.org/0000-0002-1991-0923)
- Julio Flores‐González (ORCID: https://orcid.org/0000-0003-4707-718X)
- Leslie Chávez‐Galán (ORCID: https://orcid.org/0000-0002-2334-0361)
- Beda Islas‐Muñoz (ORCID: https://orcid.org/0000-0002-8720-617X)
Institutions
- Instituto Nacional de Enfermedades Respiratorias (MX)
- Instituto Nacional de Cancerología (MX)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1625386
- Primary Topic
- Viral-associated cancers and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00