Single-cell and machine learning-based pyroptosis-related gene signature predicts prognosis and immunotherapy response in glioblastoma
This study systematically elucidates the role of pyroptosis in GBM and establishes PRGS as a reliable prognostic biomarker. PRGS not only refines risk stratification and predicts immunotherapy response but also provides molecular insights into tumor metabolism and immune regulation, thereby offering potential avenues for targeted therapeutic strategies in GBM.
Authors
- Yinzhi Wang (ORCID: https://orcid.org/0000-0001-8505-0223)
- Lin Fang (ORCID: https://orcid.org/0000-0002-1097-148X)
- Congjun Li (ORCID: https://orcid.org/0000-0003-1389-9820)
- Feng Lu (ORCID: https://orcid.org/0000-0003-3933-8490)
- Fanbo Meng (ORCID: https://orcid.org/0000-0002-1356-445X)
- Desheng Wang (ORCID: https://orcid.org/0009-0004-4620-8242)
Institutions
- Taizhou Central Hospital (CN)
- Second Hospital of Tianjin Medical University (CN)
- Tianjin Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1693940
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52