Scorpion-Centipede extracts mitigate ovariectomy-induced osteoporosis in mice through facilitating Cx3cr1 expression
This study demonstrates that the SC effectively increases bone mass and osteogenesis by promoting Cx3cr1, thereby increasing osteogenic differentiation and inhibiting adipogenic differentiation. These findings amplified the mechanisms of SC and its potential to treat PMOP.
Authors
- J. Ni
- Min Wen (ORCID: https://orcid.org/0000-0001-8897-1239)
- Bin Du (ORCID: https://orcid.org/0000-0001-6237-2895)
- Wenbin Shang (ORCID: https://orcid.org/0000-0002-0317-5928)
- Bingjie Wang (ORCID: https://orcid.org/0000-0003-0441-0261)
- Penghua Fang (ORCID: https://orcid.org/0000-0002-8915-0616)
- Shuai Chen (ORCID: https://orcid.org/0000-0001-9455-6015)
- Lingling Yu (ORCID: https://orcid.org/0000-0002-9363-2802)
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-24
- DOI
- https://doi.org/10.3389/fphar.2025.1604096
- Primary Topic
- Neuropeptides and Animal Physiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00