Micro-geographic variation in antigenic diversity of PfEBA-175 region II in asymptomatic Plasmodium falciparum infections in Tanzania
Despite substantial polymorphism, the glycan-binding residues of PfEBA-175 RII remain conserved, and its high antigenicity across diverse geographic and demographic contexts supports its continued evaluation as a blood-stage vaccine candidate. These findings highlight the importance of accounting for naturally occurring antigenic variation in malaria vaccine development.
Authors
- Alphaxard Manjurano (ORCID: https://orcid.org/0000-0001-7583-6425)
- Se Jin Lee (ORCID: https://orcid.org/0000-0002-8626-6250)
- Md Atique Ahmed (ORCID: https://orcid.org/0000-0002-3407-7220)
- Bo‐Young Jeon (ORCID: https://orcid.org/0000-0002-4314-216X)
- Jin‐Hee Han (ORCID: https://orcid.org/0000-0003-0836-6675)
- Fauzi Muh (ORCID: https://orcid.org/0000-0002-3966-9110)
- Winifrida Kidima (ORCID: https://orcid.org/0000-0003-3344-7725)
- Hojong Jun (ORCID: https://orcid.org/0009-0009-8364-3047)
- Wanjoo Chun (ORCID: https://orcid.org/0000-0003-1984-3545)
- Jim Todd (ORCID: https://orcid.org/0000-0001-5918-4914)
- Sunghun Na (ORCID: https://orcid.org/0000-0002-2803-8356)
- Wang-Jong Lee (ORCID: https://orcid.org/0000-0003-2152-8915)
- Ernest Mazigo (ORCID: https://orcid.org/0000-0002-8044-7384)
- Johnsy Mary Louis (ORCID: https://orcid.org/0009-0005-1896-9017)
- Won Sun Park (ORCID: https://orcid.org/0000-0001-5868-3797)
- Eun‐Taek Han (ORCID: https://orcid.org/0000-0003-1962-7199)
- Feng Lu (ORCID: https://orcid.org/0000-0002-4150-4366)
- Fadhila Fitriana
- Jadidan Hada Syahada
Institutions
- Diponegoro University (ID)
- University of London (GB)
- Kangwon National University (KR)
- University of Dar es Salaam (TZ)
- Yonsei University (KR)
- Catholic University of Health and Allied Sciences (TZ)
- London School of Hygiene & Tropical Medicine (GB)
- Regional Medical Research Centre (IN)
- Kangwon National University Hospital (KR)
- National Institute for Medical Research (TZ)
- Yangzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1656267
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Education, India
- Ministry of Science and ICT, South Korea