Comparative transcriptomic analysis of tumor- infiltrating canine natural killer cells and candidate biomarkers from first-in-dog NK immunotherapy trials
Overall, NK effector functions are well adapted to their tissue of residence but dysregulated in sarcoma infiltrating NK cells despite enhanced migration. We describe NK cell trends across canine clinical trials as a platform through which we can elucidate mechanisms of response and determine novel immunotherapy strategies to improve cancer outcomes in both humans and dogs.
Authors
- Michael S. Kent (ORCID: https://orcid.org/0000-0002-7703-7720)
- Zachary S. Morris (ORCID: https://orcid.org/0000-0001-5558-3547)
- C. Titus Brown (ORCID: https://orcid.org/0000-0001-6001-2677)
- Cyrus J. Sholevar
- David M. Vail (ORCID: https://orcid.org/0000-0002-1964-3693)
- William T. N. Culp (ORCID: https://orcid.org/0000-0001-6132-156X)
- Aryana M. Razmara (ORCID: https://orcid.org/0000-0002-3834-3442)
- Cameron E. Gaskill (ORCID: https://orcid.org/0000-0002-3848-3357)
- Robert B. Rebhun (ORCID: https://orcid.org/0000-0002-8047-3494)
- Marshall Lammers (ORCID: https://orcid.org/0000-0003-2237-847X)
- Robert J. Canter (ORCID: https://orcid.org/0000-0002-3331-5418)
- Sean J. Judge (ORCID: https://orcid.org/0000-0002-1842-9468)
- William J. Murphy (ORCID: https://orcid.org/0000-0002-9732-3353)
- Alicia A. Gingrich (ORCID: https://orcid.org/0000-0002-7239-0154)
Institutions
- University of Wisconsin–Madison (US)
- University of California Davis Medical Center (US)
- University of California, Davis (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1646849
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Research Coordinating Committee
- National Institutes of Health
- University of California, Davis
- National Cancer Institute
- Genome Center, University of California, Davis
- Comprehensive Cancer Center, University of California, Davis