Pd-catalysed flow Tsuji–Trost allylation of phenols: continuous-flow, extraction-free synthesis of esmolol <i>via</i> allylation, epoxidation, and aminolysis
A Tsuji–Trost allylation for phenols using a heterogeneous Pd catalyst and allyl methyl carbonate, eliminating the need for halide-based reagents and bases, is reported. Through the integrated continuous-flow process, esmolol can be synthesized.
Authors
- Masayuki Yamashita (ORCID: https://orcid.org/0000-0001-9459-4329)
- Tatsuo Kimura (ORCID: https://orcid.org/0000-0002-5184-046X)
- Kwihwan Kobayashi (ORCID: https://orcid.org/0000-0002-5289-8348)
- Shun‐ya Onozawa (ORCID: https://orcid.org/0000-0001-5786-4035)
- Shu̅ Kobayashi (ORCID: https://orcid.org/0000-0002-8235-4368)
- Yoshihiro Kon (ORCID: https://orcid.org/0000-0002-7217-0557)
- Takuya Nakashima (ORCID: https://orcid.org/0000-0002-5311-4146)
Institutions
- National Institute of Advanced Industrial Science and Technology (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5qo01336d
- Citations
- 1
- Primary Topic
- Innovative Microfluidic and Catalytic Techniques Innovation
- Type
- article
- Field-Weighted Citation Impact
- 0.67