The Endothelium as a Central Mediator of Exercise-Induced Metabolism and Communication

Cells lining the capillary endothelium, endothelial cells (ECs), play central roles in local and systemic metabolisms by sensing and responding to exercise-induced stresses. ECs release and respond to many factors, coordinating intra- and interorgan communication, supporting angiogenesis, and enhancing oxidative and global metabolism. Their widespread distribution positions them as key regulators of exercise-induced metabolic rewiring.