Intravenous thrombolysis in patients with acute ischemic stroke and cerebral microbleeds: Results from the ENCHANTED trial
In ENCHANTED, CMB(s) was associated with 90-day unfavorable function recovery but not with a significantly increased likelihood of ICH in post-intravenous thrombolytic AIS. Low-dose alteplase may not offer a better profile for AIS with CMB(s).Data access statement:Individual de-identified participant data used in this analysis will be shared by request from any qualified investigator via the Research Office of The George Institute for Global Health.
Authors
- Joanna Marguerite Wardlaw (ORCID: https://orcid.org/0000-0002-9812-6642)
- Zien Zhou (ORCID: https://orcid.org/0000-0001-6543-7113)
- Takako Torii-Yoshimura
- Xiaoqiu Liu (ORCID: https://orcid.org/0000-0001-8620-6592)
- Sohei Yoshimura (ORCID: https://orcid.org/0000-0002-4751-3538)
- Grant Mair (ORCID: https://orcid.org/0000-0003-2189-443X)
- Candice Delcourt (ORCID: https://orcid.org/0000-0003-2257-4286)
- Allen S. Craig
- Richard I. Lindley (ORCID: https://orcid.org/0000-0002-0104-5679)
- Mark William Parsons (ORCID: https://orcid.org/0000-0001-8874-2487)
- Cheryl E. Carcel (ORCID: https://orcid.org/0000-0001-8942-953X)
- Xiaoying Chen (ORCID: https://orcid.org/0000-0002-8367-542X)
- Yuki Sakamoto (ORCID: https://orcid.org/0000-0001-8353-1787)
- Leibo Liu (ORCID: https://orcid.org/0000-0002-7517-0050)
- Yilun Ge
Institutions
- The University of Sydney (AU)
- Fudan University (CN)
- UNSW Sydney (AU)
- Nagoya City University (JP)
- Soochow University (CN)
- Shanghai Institute for Science of Science (CN)
- The George Institute for Global Health (AU)
- National Cerebral and Cardiovascular Center (JP)
- Second Affiliated Hospital of Soochow University (CN)
- UK Dementia Research Institute (GB)
- South Western Sydney Local Health District (AU)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
- Nippon Medical School (JP)
- University of Edinburgh (GB)
- Macquarie University (AU)
Publication Details
- Journal
- International Journal of Stroke
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1177/17474930251392751
- Citations
- 2
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78