Identification of CAF signature genes and construction of CAF-based risk signature in hepatocellular carcinoma by multi-omics analysis
This study presents a novel CAF-based risk model that can exhibits accurately predict the prognosis of HCC patients. Furthermore, knockdown of OLFML2B attenuates the CAF-induced HCC progression, suggesting it as a potential therapeutic target.
Authors
- Bowen Ni
- Kezhi Wu
- Wenqi Qian (ORCID: https://orcid.org/0000-0003-0928-1542)
- Manlan Guo
- Zhu Shen
- Yawei Liu (ORCID: https://orcid.org/0000-0003-4535-5019)
- Haojie Zheng
Institutions
- Central South University (CN)
- Guilin Medical University (CN)
- The First People's Hospital of Shunde (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1690174
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00