Single-cell RNA sequencing analysis reveals the critical role of fibroblasts in aortic progeria-associated vascular remodeling in Hutchinson-Gilford progeria syndrome mice
Our findings underscore the pivotal role of fibroblasts in aortic progeria-associated vascular remodeling in HGPS mice and suggest that <i>Lgals3bp</i> may represent a potential therapeutic target for aortic pathology in HGPS.
Authors
- Qian Sun (ORCID: https://orcid.org/0000-0001-6341-6036)
- Qianying Hu (ORCID: https://orcid.org/0000-0001-5902-6457)
- Zilong Zhou (ORCID: https://orcid.org/0009-0006-9170-8689)
- Xianling Cong (ORCID: https://orcid.org/0000-0002-5790-4188)
- Linsen Yang (ORCID: https://orcid.org/0000-0003-2410-6435)
- Nan Wu (ORCID: https://orcid.org/0000-0003-0826-3836)
- Chunyi Li (ORCID: https://orcid.org/0000-0001-7275-4440)
Institutions
- Union Hospital (HK)
- Jilin University (CN)
- Union Hospital (CN)
- Changchun University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1638083
- Citations
- 1
- Primary Topic
- Nuclear Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.81