Multi-omic analysis of PBMCs in sepsis reveals widespread cytotoxic dysfunction and an increased population of CD69 expressing naïve CD4+ T cells
These results identify potential mechanisms underlying the functional impairment witnessed in sepsis. Such mechanisms may inform future diagnostic and treatment strategies.
Authors
- Michael Carty (ORCID: https://orcid.org/0000-0003-1588-7479)
- Orla Sheils (ORCID: https://orcid.org/0000-0002-4493-9496)
- Derek G. Doherty (ORCID: https://orcid.org/0000-0002-4394-658X)
- Joshua Flynn (ORCID: https://orcid.org/0000-0003-4022-5434)
- Elaine Kenny (ORCID: https://orcid.org/0000-0003-4676-3436)
- Lisa McDermott (ORCID: https://orcid.org/0000-0001-9419-0666)
- Ciara S. McNevin (ORCID: https://orcid.org/0000-0003-3587-4018)
- Anne‐Marie Baird (ORCID: https://orcid.org/0000-0001-7501-1159)
- John Davis Coakley (ORCID: https://orcid.org/0000-0002-3607-6109)
- Thomas Ryan (ORCID: https://orcid.org/0000-0002-3556-5592)
- Eamon P. Breen
Institutions
- Trinity College (CA)
- Trinity College Dublin (IE)
- St. James's Hospital (IE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1667186
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00