A simulation study comparing anticholinergic drug use with polypharmacy for risk of death, dementia, and delirium in UK Biobank
The models show an anticholinergic effect of drugs beyond polypharmacy or drug count, but it is small, ABS-dependent, and varies between outcomes.
Authors
- Lucy Stirland (ORCID: https://orcid.org/0000-0002-5678-4583)
- Graciela Muñiz‐Terrera (ORCID: https://orcid.org/0000-0002-4516-0337)
- Anja Leist (ORCID: https://orcid.org/0000-0002-5074-5209)
- Jure Mur (ORCID: https://orcid.org/0000-0002-0103-5139)
Institutions
- University of California, San Francisco (US)
- University of Luxembourg (LU)
- Ohio University (US)
- MRC Centre for Regenerative Medicine (GB)
- Luxembourg Institute of Socio-Economic Research (LU)
- Global Brain Health Institute (US)
- University of Edinburgh (GB)
Publication Details
- Journal
- The Journals of Gerontology Series A
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1093/gerona/glaf232
- Citations
- 1
- Primary Topic
- Pharmaceutical Practices and Patient Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.22
Funders
- Université du Luxembourg
- Directorate for Biological Sciences