Magnetic Induction Heating Enables On-Demand Drug Release via Diels–Alder Polymeric Nanocarriers
As a stimulus-responsive drug release system, we developed Diels-Alder (DA) induction-activated magnetic nanoparticles (DiMaN). Functionalization of polymer-coated magnetic nanoparticles (mNPs) with drugs via thermoreversible DA coupling enabled release through retro-Diels-Alder (rDA) cleavage upon heating. The (pDMAm-<i>co</i>-pFMA)-<i>b</i>-pAAc polymer supported mNP formation and drug binding. DA coupling with maleimide-functionalized drugs was verified by <sup>1</sup>H NMR, showing distinct exo (3.23 ppm) and endo (3.48 ppm) signals after 72 h at 37 °C. Approximately 70% release was observed within 15 min at 80 °C, while the complex maintained stability at 40 °C. The superparamagnetic mNPs generated localized heating under an alternating current magnetic field (192 kHz, 480 A), raising the solution temperature by 6 °C within 5 min. The biotin-maleimide complex demonstrated higher release by rDA from furan-containing mNPs (approximately 150 μM) compared to the control group (approximately 103 μM). These results highlight DiMaN as a promising platform for magnetic-controlled, on-demand drug release.
Authors
- James J. Lai (ORCID: https://orcid.org/0000-0003-3437-7810)
- Nanami Fujisawa (ORCID: https://orcid.org/0000-0002-8894-1790)
- Mitsuhiro Ebara (ORCID: https://orcid.org/0000-0002-7906-0350)
Institutions
- University of Tsukuba (JP)
- National Taiwan University of Science and Technology (TW)
- University of Washington (US)
- National Institute for Materials Science (JP)
Publication Details
- Journal
- Biomacromolecules
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1021/acs.biomac.5c00321
- Primary Topic
- nanoparticles nucleation surface interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00