Burden of psychiatric disease inversely correlates with Alzheimer's age at onset
Retrospective chart review revealed that in patients with AD, those who also had depression, anxiety, or post-traumatic stress disorder were significantly younger at age at onset than those without. Increasing burden of psychiatric disease, both in severity of psychiatric symptoms and number of comorbid psychiatric conditions, produced serial decreases in the age at onset of AD. In patients with AD, those with depression were more likely to have autoimmune disease, and those with anxiety were more likely to have a history of seizures.
Authors
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- Joel H. Kramer (ORCID: https://orcid.org/0000-0002-2917-8297)
- Salvatore Spina (ORCID: https://orcid.org/0000-0003-3570-9143)
- Rian Bogley
- Emily Eijansantos
- Jessica Deleon (ORCID: https://orcid.org/0000-0002-9779-0541)
- Stephanie M. Grasso (ORCID: https://orcid.org/0000-0001-5287-3012)
- Gil D. Rabinovici (ORCID: https://orcid.org/0000-0002-3626-4265)
- Zachary Miller (ORCID: https://orcid.org/0000-0002-5991-3053)
- Isabel Elaine Allen (ORCID: https://orcid.org/0000-0001-9029-9744)
- David C. Perry (ORCID: https://orcid.org/0000-0003-3098-8593)
- Maxime Montembeault (ORCID: https://orcid.org/0000-0002-9369-0498)
- Virginia E. Sturm (ORCID: https://orcid.org/0000-0002-1717-298X)
- Howard J. Rosen (ORCID: https://orcid.org/0000-0001-9281-7402)
- Katherine P. Rankin (ORCID: https://orcid.org/0000-0002-3611-0848)
- Alexander J. Ehrenberg (ORCID: https://orcid.org/0000-0003-4334-9424)
- Nicole Rogers (ORCID: https://orcid.org/0000-0002-9878-6077)
- Bruce L. Miller
- William W. Seeley
- Maria Luisa Gorno‐Tempini
- Andrew Paramo
Institutions
- Orlando Health (US)
- University of California, San Francisco (US)
- Douglas Mental Health University Institute (CA)
- University of California System (US)
- Language Computer (United States) (US)
- Global Brain Health Institute (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70677
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16