A semi‐automated <scp>ASC</scp> speck assay to evaluate pyrin inflammasome activation
The semi-automated ASC speck assay may be a useful test to functionally validate VUS in the <i>MEFV</i> gene and screen for pyrin inflammasome overactivity.
Authors
- Alberto Pinzón‐Charry (ORCID: https://orcid.org/0000-0001-8870-6304)
- Tri Giang Phan (ORCID: https://orcid.org/0000-0002-4909-2984)
- Stephanie Ruiz‐Diaz (ORCID: https://orcid.org/0000-0003-4871-5980)
- Katie Frith (ORCID: https://orcid.org/0000-0002-7258-1348)
- Matthew Parker (ORCID: https://orcid.org/0000-0002-6550-1995)
- Pei Dai (ORCID: https://orcid.org/0000-0002-9022-5101)
- Brynn Wainstein (ORCID: https://orcid.org/0000-0001-5704-650X)
- Paul Gray
- Leonard D. Goldstein (ORCID: https://orcid.org/0000-0003-4645-553X)
- Oliver P. Skinner (ORCID: https://orcid.org/0000-0003-0898-4131)
- Ming‐Wei Lin (ORCID: https://orcid.org/0000-0002-5471-7731)
- Rohit G. Saldanha
- Xufeng Lin (ORCID: https://orcid.org/0000-0002-3400-8700)
- Stephen Adelstein (ORCID: https://orcid.org/0000-0001-7221-6298)
- Elissa K. Deenick (ORCID: https://orcid.org/0000-0002-9271-0004)
- Kahn Preece (ORCID: https://orcid.org/0000-0002-7326-6585)
- Winnie Tong (ORCID: https://orcid.org/0000-0003-2235-8452)
- Michael J. Rogers
- Anna Sullivan
- Laila Girgis
- Samar Ojami
- Aiden Telfser
Institutions
- The University of Sydney (AU)
- Garvan Institute of Medical Research (AU)
- Royal Prince Alfred Hospital (AU)
- Bankstown Lidcombe Hospital (AU)
- Nepean Hospital (AU)
- Westmead Hospital (AU)
- UNSW Sydney (AU)
- St Vincent's Hospital Melbourne (AU)
- St Vincent's Hospital Sydney (AU)
- St Vincent’s Private Hospital Sydney (AU)
- Peter Doherty Institute (AU)
- The George Institute for Global Health (AU)
- Monash Health (AU)
- St Vincent's Clinic (AU)
- Sydney Children's Hospital (AU)
- John Hunter Children's Hospital (AU)
- Westmead Institute for Medical Research (AU)
- Children's Health Queensland Hospital and Health Service (AU)
- Monash University (AU)
- Western Sydney University (AU)
- Neuroscience Research Australia (AU)
Publication Details
- Journal
- Clinical & Translational Immunology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/cti2.70054
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of New South Wales
- National Health and Medical Research Council