Cutaneous metastasis of high-grade serous adenocarcinoma secondary to a gynecological malignancy

Cutaneous metastases from malignancies of gynecological origin are rare but have been described over the vulvovaginal area in the setting of ovarian, endometrial, and fallopian tube neoplasia. We present an 89-year-old woman with multiple non-tender, fleshy, skin-colored nodules with central ulceration and bleeding over the mons pubis. Skin biopsy and immunohistochemistry of these tumors were in keeping with metastatic high-grade serous adenocarcinoma secondary to a gynecological malignancy. This brief report aims to raise physician awareness about this rare skin presentation, which is unfortunately associated with a poor prognosis.

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Publication Details

Journal
Dermatology Online Journal
Published
2025-09-08
DOI
https://doi.org/10.25251/0bz3fk76
Primary Topic
Cancer Diagnosis and Treatment
Type
article
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article

Cutaneous metastasis of high-grade serous adenocarcinoma secondary to a gynecological malignancy

Godfrey Baldacchino, Stephanie Farrugia, David Pisani, Michael John Boffa
Dermatology Online Journal
Cancer Diagnosis and Treatment
article

Cutaneous metastasis of high-grade serous adenocarcinoma secondary to a gynecological malignancy

Godfrey Baldacchino, Stephanie Farrugia, David Pisani, Michael John Boffa
article en

Abstract

Cutaneous metastases from malignancies of gynecological origin are rare but have been described over the vulvovaginal area in the setting of ovarian, endometrial, and fallopian tube neoplasia. We present an 89-year-old woman with multiple non-tender, fleshy, skin-colored nodules with central ulceration and bleeding over the mons pubis. Skin biopsy and immunohistochemistry of these tumors were in keeping with metastatic high-grade serous adenocarcinoma secondary to a gynecological malignancy. This brief report aims to raise physician awareness about this rare skin presentation, which is unfortunately associated with a poor prognosis.

Dermatology Online JournalVol. 31(4)
University of South Wales (GB), Mater Dei Hospital (MT)
Openalex Percentile: Top 59%
Cancer Diagnosis and Treatment
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