Intra-plaque vascularization assessed in contrast-enhanced ultrasound predicts cardiovascular events in type 2 diabetes with no significant carotid atherosclerotic stenosis: a prospective study with therapeutic implications for SGLT2 inhibitor use
CEUS-detected IPV predicts cardiovascular events in T2DM patients without significant stenosis. SGLT2i may reduce risk by modulating plaque inflammation and angiogenesis. CEUS combined with biomarker profiling may support personalized prevention strategies in diabetes.
Authors
- Luca Rinaldi (ORCID: https://orcid.org/0000-0002-6541-3821)
- Caterina Carusone
- Ciro Romano (ORCID: https://orcid.org/0000-0002-5807-6601)
- Lorenza Marfella
- Raffaele Marfella (ORCID: https://orcid.org/0000-0003-3960-9270)
- Ludovica Vittoria Marfella
- Fulvio Furbatto
- Salvatore Cappabianca (ORCID: https://orcid.org/0000-0002-5417-2268)
- Maria Luisa Balestrieri (ORCID: https://orcid.org/0000-0001-6001-1789)
- Nunzia D’Onofrio (ORCID: https://orcid.org/0000-0002-5300-9530)
- Ciro Mauro (ORCID: https://orcid.org/0000-0003-3611-2330)
- Luca Marinelli (ORCID: https://orcid.org/0000-0001-7775-5952)
- Pasquale Russo (ORCID: https://orcid.org/0000-0002-6733-9573)
- Ferdinando Carlo Sasso (ORCID: https://orcid.org/0000-0002-9142-7848)
- S Gentile
- Alessandro Bellis (ORCID: https://orcid.org/0000-0003-3476-5696)
- Nicola Tarantino (ORCID: https://orcid.org/0000-0002-9770-8675)
- Giuseppina Guarino (ORCID: https://orcid.org/0000-0002-5057-9650)
- Francesco Nappo
- Gerardo Carpinella
- Ersilia Satta (ORCID: https://orcid.org/0000-0001-8154-287X)
- Celestino Sardu (ORCID: https://orcid.org/0000-0001-5099-3790)
- Carlo Fumagalli (ORCID: https://orcid.org/0000-0001-7963-5049)
- Isabella Donisi
- Domenico Cozzolino (ORCID: https://orcid.org/0000-0003-4968-8160)
- Ausilia Sellitto
- Giuseppe Diodato
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
- Education and Research Network (IN)
- Ospedale Antonio Cardarelli (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- NIHR Research Delivery Network (GB)
Publication Details
- Journal
- European Heart Journal - Imaging Methods and Practice
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1093/ehjimp/qyaf129
- Primary Topic
- Cerebrovascular and Carotid Artery Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00