Impact of Abemaciclib-Induced Serum Creatinine Elevation on Dose Adjustment of Concomitant Medications
ABE administration led to Scr elevation and changes in renal function classification in approximately half of patients, impacting dose adjustment of concomitant renally excreted medications. Therefore, appropriate management methods, including cystatin C-based renal evaluation, are necessary.
Authors
- Kengo Umehara
- M. Yamamoto
- Nobumoto Tomioka (ORCID: https://orcid.org/0000-0001-6751-416X)
- Hiroyuki Kawaguchi (ORCID: https://orcid.org/0000-0001-8503-9278)
- Kenichi Watanabe (ORCID: https://orcid.org/0000-0002-5269-146X)
- Y. Saito (ORCID: https://orcid.org/0000-0002-4957-6129)
- Shinya Takada (ORCID: https://orcid.org/0000-0002-6845-5533)
Institutions
- Hokkaido University of Science (JP)
- Hokkaido Pharmaceutical University (JP)
- National Hospital Organization Hokkaido Medical Center (JP)
- Japan Cancer Society (JP)
Publication Details
- Journal
- Oncology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1159/000548669
- Primary Topic
- Advanced Breast Cancer Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00