Prospective Study of Annual Whole-Body Magnetic Resonance Imaging as Part of a Multimodality Screening Program for Individuals With Li-Fraumeni Syndrome
Annual WBMRI contributes substantially to the detection of asymptomatic localized cancers among individuals with LFS and is best used in conjunction with a multimodality approach endorsed by LFS guidelines. Our study highlights the need for further research to enhance early detection and interception of cancer in LFS.
Authors
- Megan N. Frone (ORCID: https://orcid.org/0000-0001-8273-8866)
- Junne Kamihara (ORCID: https://orcid.org/0000-0002-2852-7387)
- Wendy B. London (ORCID: https://orcid.org/0000-0003-3571-6538)
- Judy Ellen Garber (ORCID: https://orcid.org/0000-0001-9449-3982)
- Sophie Hyman (ORCID: https://orcid.org/0000-0001-7456-0113)
- Katherine A. Schneider
- Lisa Diller (ORCID: https://orcid.org/0000-0002-4073-5509)
- Jaclyn Schienda (ORCID: https://orcid.org/0000-0003-2543-8378)
- Michael F. Walsh (ORCID: https://orcid.org/0000-0001-5006-6778)
- Asaf Maoz (ORCID: https://orcid.org/0000-0002-7502-3923)
- Stephan D. Voss (ORCID: https://orcid.org/0000-0002-2092-2219)
- Danielle Novetsky Friedman (ORCID: https://orcid.org/0000-0003-4668-9176)
- Mark E. Robson (ORCID: https://orcid.org/0000-0002-3109-1692)
- Jyothi P. Jagannathan
- Alison Schwartz (ORCID: https://orcid.org/0000-0003-3861-4203)
- Puja J. Umaretiya (ORCID: https://orcid.org/0000-0002-7587-4875)
- Allison F. O’Neill (ORCID: https://orcid.org/0000-0002-8957-3870)
- Bita Nehoray (ORCID: https://orcid.org/0000-0003-3534-4607)
- Kayla V. Hamilton (ORCID: https://orcid.org/0000-0002-5196-370X)
- Huma Q. Rana (ORCID: https://orcid.org/0000-0002-1598-6752)
- Nan Chen (ORCID: https://orcid.org/0000-0002-0822-125X)
- Andrea Onufrychuk
Institutions
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- National Institutes of Health (US)
- City Of Hope National Medical Center (US)
- Memorial Sloan Kettering Cancer Center (US)
- Harvard University (US)
- Dana-Farber Cancer Institute (US)
- National Cancer Institute (US)
- Boston Children's Museum (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1200/po-25-00264
- Citations
- 1
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.05