Intrahepatic Cholangiocarcinoma: Recurrence Patterns, Genomics, and Survival
Recurrence after resection of IHC is common, and the liver was the most common site (66%). Clinicopathologic and genomic factors had limited ability to predict SOFR. Although LO and EH were associated with similar OS, SIM recurrences had dramatically worse OS. Adjuvant strategies targeting liver recurrence may improve outcomes after resection of IHC.
Authors
- Alice C. Wei (ORCID: https://orcid.org/0000-0002-2505-959X)
- Michael I. D’Angelica (ORCID: https://orcid.org/0000-0002-3731-0534)
- Louise C. Connell (ORCID: https://orcid.org/0000-0002-3193-4629)
- Bas Groot Koerkamp (ORCID: https://orcid.org/0000-0003-1917-6973)
- Andrea Cercek (ORCID: https://orcid.org/0000-0002-5054-8192)
- Wungki Park (ORCID: https://orcid.org/0000-0002-8006-3102)
- William R. Jarnagin (ORCID: https://orcid.org/0000-0002-1635-5768)
- Pratik Chandra (ORCID: https://orcid.org/0009-0008-1243-4865)
- Esther N Drill (ORCID: https://orcid.org/0000-0002-3315-4538)
- Kevin C. Soares (ORCID: https://orcid.org/0000-0002-0406-017X)
- Vinod P. Balachandran (ORCID: https://orcid.org/0000-0002-2956-223X)
- James J. Harding (ORCID: https://orcid.org/0000-0002-7029-4310)
- Nancy E. Kemeny (ORCID: https://orcid.org/0000-0002-0929-9542)
- T. Peter Kingham (ORCID: https://orcid.org/0000-0002-3359-3186)
- Eileen Mary O'Reilly (ORCID: https://orcid.org/0000-0002-8076-9199)
- Jeffrey A. Drebin (ORCID: https://orcid.org/0000-0003-2312-2062)
- Ghassan K. Abou‐Alfa (ORCID: https://orcid.org/0000-0002-1522-8054)
- Yi Song (ORCID: https://orcid.org/0000-0003-0125-6019)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Trinity College Dublin (IE)
- Cornell University (US)
- Erasmus MC (NL)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1200/po-25-00402
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00