Neurofilament Light Chain as a Biomarker of Disease Progression in Lafora Disease
Our findings support the utility of NfL, particularly sNfL, as a promising biomarker of disease progression in LD. While further research is needed to fully elucidate the potential of NfL in this context, it holds immediate promise as an exploratory outcome measure in ongoing and future clinical trials.
Authors
- Dávid Brenner (ORCID: https://orcid.org/0000-0002-1535-3146)
- Souad Messahel
- Lorenzo Muccioli (ORCID: https://orcid.org/0000-0001-6827-0099)
- Francesca Bisulli (ORCID: https://orcid.org/0000-0002-1109-7296)
- Hayrettin Tumani (ORCID: https://orcid.org/0000-0002-1647-6201)
- Jan Wagner (ORCID: https://orcid.org/0000-0002-0459-8885)
- Mayank Verma (ORCID: https://orcid.org/0000-0003-0167-0842)
- Maria Tappatà (ORCID: https://orcid.org/0000-0002-3397-6996)
- Berge A. Minassian
- Jochen Hans Weishaupt (ORCID: https://orcid.org/0000-0002-3399-9784)
- Raffaella Minardi (ORCID: https://orcid.org/0000-0002-8190-8517)
- Felix Nitschké (ORCID: https://orcid.org/0000-0002-1118-2693)
- Franziska Bachhuber (ORCID: https://orcid.org/0000-0003-1031-9966)
- Mahmoud Alkhatib (ORCID: https://orcid.org/0000-0002-8294-8000)
- Felicitas Becker
- Sebahattin Çirak
- Bazile Ganceviciute
Institutions
- Universität Ulm (DE)
- German Center for Neurodegenerative Diseases (DE)
- German Center for Pediatric and Adolescent Rheumatology (DE)
- Southwestern Medical Center (US)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- University Hospital Ulm (DE)
- The University of Texas Southwestern Medical Center (US)
- University of Bologna (IT)
Publication Details
- Journal
- Neurology Genetics
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1212/nxg.0000000000200319
- Primary Topic
- Glycogen Storage Diseases and Myoclonus
- Type
- article
- Field-Weighted Citation Impact
- 0.00