RORγ Hijacks HIF1α to Promote Peritoneal Metastasis of Gastric Cancer

RORγ drives peritoneal metastasis in gastric cancer and can be targeted to block metastatic progression, suggesting that RORγ inhibition could serve as a therapeutic strategy for advanced gastric cancer.

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Publication Details

Journal
Cancer Research
Published
2025-10-23
DOI
https://doi.org/10.1158/0008-5472.can-25-1690
Primary Topic
Cancer, Hypoxia, and Metabolism
Type
article
Field-Weighted Citation Impact
0.00
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article

RORγ Hijacks HIF1α to Promote Peritoneal Metastasis of Gastric Cancer

Huihao Zhou, Guodi Cai, Xiaojuan Wang, Franky Leung Chan et al.
Cancer Research
Cancer, Hypoxia, and Metabolism
article

RORγ Hijacks HIF1α to Promote Peritoneal Metastasis of Gastric Cancer

Huihao Zhou, Guodi Cai, Xiaojuan Wang, Franky Leung Chan, Fanghai Han, Zhenhua Zhang, Zhiying Huang, Qianqian Wang, Qingwen Zhang, Lin Shen, Hong Wang, Peiqing Liu, Lin Zhong, Junjian Wang, Bin Yang, Haolong Li, Zhanfeng Gu
article en

Abstract

RORγ drives peritoneal metastasis in gastric cancer and can be targeted to block metastatic progression, suggesting that RORγ inhibition could serve as a therapeutic strategy for advanced gastric cancer.

Cancer ResearchVol. 86(3)
University of Electronic Science and Technology of China (CN), Sun Yat-sen University (CN), Jinan University (CN), Chinese University of Hong Kong (HK), Guangdong Pharmaceutical University (CN), Peking University (CN), University of Macau (MO), Second Affiliated Hospital of Guangzhou Medical University (CN), Peking University Cancer Hospital (CN), Sun Yat-sen Memorial Hospital (CN), Ministry of Education (ET), Beijing Tsinghua Chang Gung Hospital (CN), Guangdong Provincial People's Hospital (CN), Guangzhou Medical University (CN), Tsinghua University (CN)
Openalex Percentile: Top 63%
Cancer, Hypoxia, and Metabolism
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