PRMT3 Drives IDO1-Dependent Radioresistance and Immunosuppression by Promoting Kynurenine Metabolism in Non–Small Cell Lung Cancer
PRMT3 orchestrates metabolic reprogramming in non-small cell lung cancer through a TFAP2A-IDO1 pathway that stimulates kynurenine synthesis to promote radioresistance and immunosuppression, highlighting this axis as a putative therapeutic target.
Authors
- Gen Li
- Yixue Wang
- Yunyan Zhang (ORCID: https://orcid.org/0000-0003-3352-4241)
- Tong Zhou (ORCID: https://orcid.org/0009-0003-8162-1553)
- Jun‐Pu Xu
- Siyu Wang (ORCID: https://orcid.org/0009-0004-0793-2422)
- Xiaoyuan Wang (ORCID: https://orcid.org/0000-0001-5186-8668)
- Shijie Zhang (ORCID: https://orcid.org/0000-0002-9606-9955)
- Jiaxin Yang (ORCID: https://orcid.org/0009-0002-9768-1799)
- Hang Yin (ORCID: https://orcid.org/0009-0005-1156-7306)
Institutions
- Hong Kong Polytechnic University (HK)
- Harbin Medical University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1158/0008-5472.can-24-4162
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61