Alkane Chain-Bearing Pyridylboronic Acid-Grafted Graphitic Carbon Nitride-Loaded Polyacrylonitrile Membrane for Efficient Photocatalytic Bacterial Killing
A positively charged ammonium side chain, a pyridylboronic acid side chain, and mixed two moieties were grafted on intrinsic <i>g</i>-<b>C</b><sub><b>3</b></sub><b>N</b><sub><b>4</b></sub> to yield functionalized materials, <i>g</i>-<b>C</b><sub><b>3</b></sub><b>N</b><sub><b>4</b></sub>-<b>C</b><sub><b>4</b></sub>, <i>g</i>-<b>C</b><sub><b>3</b></sub><b>N</b><sub><b>4</b></sub>-<b>B</b>, and <i>g</i>-<b>C</b><sub><b>3</b></sub><b>N</b><sub><b>4</b></sub>-<b>C</b><sub><b>4</b></sub>-<b>B</b>. All the decorated <i>g</i>-<b>C</b><sub><b>3</b></sub><b>N</b><sub><b>4</b></sub> materials displayed enhanced photocatalytic ROS (<sup>1</sup>O<sub>2</sub> and <sup>•</sup>O<sub>2</sub><sup>-</sup>) generation capabilities compared to intrinsic <i>g</i>-<b>C</b><sub><b>3</b></sub><b>N</b><sub><b>4</b></sub>. Among them, <i>g</i>-<b>C</b><sub><b>3</b></sub><b>N</b><sub><b>4</b></sub>-<b>B</b> displayed the most potent ROS generation capability. In addition, ξ potential results revealed the strongest affinity of <i>g</i>-<b>C</b><sub><b>3</b></sub><b>N</b><sub><b>4</b></sub>-<b>C</b><sub><b>4</b></sub>-<b>B</b> toward representative Gram-negative and positive bacteria (MDR <i>Acinetobacter baumannii</i> and <i>Staphylococcus aureus</i>). The photocatalytic antibacterial results demonstrated that <i>g</i>-<b>C</b><sub><b>3</b></sub><b>N</b><sub><b>4</b></sub>-<b>B</b> could achieve faster and efficient bacterial killing compared with <i>g</i>-<b>C</b><sub><b>3</b></sub><b>N</b><sub><b>4</b></sub>-<b>C</b><sub><b>4</b></sub> and <i>g</i>-<b>C</b><sub><b>3</b></sub><b>N</b><sub><b>4</b></sub>-<b>C</b><sub><b>4</b></sub>-<b>B</b> (>99% killing rates toward MDR <i>A. baumannii</i> and <i>S. aureus</i> and >95% toward <i>Escherichia coli</i>). Thus, it could be concluded that ROS generation capability plays a more important role in photocatalytic antibacterial activity over bacterial binding capability in the current case. <i>g</i>-<b>C</b><sub><b>3</b></sub><b>N</b><sub><b>4</b></sub>-<b>B</b> was further fabricated into a PAN fiber membrane for photocatalytic antibacterial application. The 0.8 wt % <i>g</i>-<b>C</b><sub><b>3</b></sub><b>N</b><sub><b>4</b></sub>-<b>B</b>-loaded PAN membrane showed potent antibacterial activities toward MDR <i>A. baumannii</i>, <i>S. aureus,</i> and <i>E. coli</i>, with efficiencies of 99.79%, 99.37%, and 99.96%, respectively. Thus, <i>g</i>-<b>C</b><sub><b>3</b></sub><b>N</b><sub><b>4</b></sub>-<b>B</b> could serve as a potent broad-spectrum photocatalytic antibacterial material. And we proposed a novel strategy for improving photocatalytic antibacterial activity for <i>g</i>-<b>C</b><sub><b>3</b></sub><b>N</b><sub><b>4</b></sub>.
Authors
- Hui Chong (ORCID: https://orcid.org/0000-0002-5847-3789)
- Junling Leng
- Yin Xu (ORCID: https://orcid.org/0000-0002-6055-297X)
- Chengyin Wang (ORCID: https://orcid.org/0000-0002-9164-1385)
- Yu Zhang (ORCID: https://orcid.org/0000-0003-1290-7980)
- Yuhuan Qiu
- Xiaofei Yang (ORCID: https://orcid.org/0000-0003-1972-4562)
- Shien Zhu
- Yuefei Zhang (ORCID: https://orcid.org/0000-0002-2684-7395)
- Weijia Song
- Shengnan Wu
Institutions
- Integrated Chinese Medicine (China) (HK)
- Northern Jiangsu People's Hospital (CN)
- Yangzhou Vocational University (CN)
- Green Chemistry (PL)
- Yangzhou University (CN)
Publication Details
- Journal
- ACS Biomaterials Science & Engineering
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1021/acsbiomaterials.5c01237
- Primary Topic
- Advanced Photocatalysis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00