Autologous Thymic Organoids Support Functional T-cell Education and Enhance Antitumor Immunity in Humanized Mice with Melanoma Xenografts
A humanized mouse xenograft model, in which T cells are educated in a patient-derived implanted thymic organoid autologous to the tumor, provides a more faithful and complete environment to study cancer immunity.
Authors
- Tugs-Saikhan Chimed (ORCID: https://orcid.org/0000-0001-8064-9165)
- Antonio Jimeno (ORCID: https://orcid.org/0000-0001-8560-0440)
- Bettina Miller (ORCID: https://orcid.org/0000-0001-8825-6526)
- Jessie M. Barra (ORCID: https://orcid.org/0000-0002-6456-9293)
- Holger A. Russ (ORCID: https://orcid.org/0000-0001-5117-2927)
- Lucas H. Armitage (ORCID: https://orcid.org/0000-0003-3179-4993)
- Stephan A. Ramos (ORCID: https://orcid.org/0000-0001-7072-9735)
- J. Jason Morton (ORCID: https://orcid.org/0000-0002-4171-8858)
- Alice N. Weaver (ORCID: https://orcid.org/0000-0002-9398-1471)
- Phuong N. Le (ORCID: https://orcid.org/0000-0001-7800-064X)
- Nathaniel Alzofon (ORCID: https://orcid.org/0009-0006-8298-346X)
- William Allen Robinson (ORCID: https://orcid.org/0000-0003-1875-9691)
- Carissa M. Thomas (ORCID: https://orcid.org/0000-0003-0765-5731)
- Dexiang Gao (ORCID: https://orcid.org/0000-0003-3920-7060)
- Stephen B. Keysar (ORCID: https://orcid.org/0000-0002-5800-857X)
- Cera Nieto (ORCID: https://orcid.org/0000-0001-8835-6236)
- Alexander S. Baker (ORCID: https://orcid.org/0009-0007-7296-7180)
- Theresa M. Medina (ORCID: https://orcid.org/0009-0002-3799-4320)
Institutions
- Colorado School of Public Health (US)
- University of Florida (US)
- University of Colorado Cancer Center (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0357
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00