Study of conditions to evaluate light hypersensitivity in a light–dark box using a mouse model and a mydriatic

"Time spent in the light box" under the condition "dark-reared and a light box with 1000 lux illuminance" was considered useful as an item for evaluating glare sensitivity. The trends in brain monoamine changes and behavioral analysis suggest that the reduction of 5-HT in the amygdala by aripiprazole and diazepam may be involved in alleviating glare sensitivity and anxiety. However, no significant behavioral change was observed, so aripiprazole/risperidone/diazepam could not be said to function clearly as a treatment for glare sensitivity.