Clinical predictors of remission in systemic juvenile idiopathic arthritis/Still's disease: insight from real-life data and the potential relevance of the 'window of opportunity'
A diagnostic and therapeutic delay predicts a longer time to reach remission in sJIA patients, and seems to affect the response to IL1 inhibition, according to the 'window of opportunity' hypothesis in sJIA treatment. A failure to IL1 inhibitors predicts a longer time to reach remission both on and off medications and is associated with an early polyarticular onset and non-monophasic disease course.
Authors
- Gabriele Simonini (ORCID: https://orcid.org/0000-0002-5919-4861)
- Ilaria Maccora (ORCID: https://orcid.org/0000-0001-6418-3254)
- Maria Vincenza Mastrolia (ORCID: https://orcid.org/0000-0002-9784-3543)
- Marine Fouillet-Desjonquères
- Alexandre Bélot (ORCID: https://orcid.org/0000-0003-4902-5332)
- Ilaria Pagnini
- Edoardo Marrani (ORCID: https://orcid.org/0000-0002-0346-3268)
- Sarah Abu‐Rumeileh (ORCID: https://orcid.org/0000-0002-6615-4788)
- Franck Zekre (ORCID: https://orcid.org/0000-0003-2479-6165)
- Audrey Laurent (ORCID: https://orcid.org/0000-0003-1282-4667)
Institutions
- Hôpital Femme Mère Enfant (FR)
- Ospedale Santa Chiara (IT)
- Meyer Children's Hospital (IT)
- Azienda Ospedaliera Universitaria Pisana (IT)
Publication Details
- Journal
- Clinical and Experimental Rheumatology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.55563/clinexprheumatol/7k95gj
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute