Reevaluating the Design of Multicenter Surgical Trials for Esophagogastric Cancer
Inadequate SQA and failure to account for surgical variability may partly explain the lack of OS benefit in multicenter surgical RCTs. Embedding SQA and internal pilot studies into trial design may improve feasibility, ensure protocol fidelity, and strengthen the validity of future trials in complex oncologic surgery.
Authors
- Anuja T. Mitra (ORCID: https://orcid.org/0000-0002-0771-7771)
- Patrick M. Bossuyt (ORCID: https://orcid.org/0000-0003-4427-0128)
- Bibek Das (ORCID: https://orcid.org/0000-0001-5982-0618)
- George B. Hanna
Institutions
- Amsterdam University Medical Centers (NL)
- Imperial College London (GB)
- University of Amsterdam (NL)
Publication Details
- Journal
- Annals of Surgical Oncology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1245/s10434-025-18532-x
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00