Unravelling tandem repeat-mediated mutagenesis drive rapid diversification of KPC enzymes: emergence of blaKPC-263 and enhanced resistance to ceftazidime-avibactam
This work was funded by the National Key R&D Programme of China (2023YFC2308400); National Natural Science Foundation of China (82072314); Shandong Provincial Laboratory Project (SYS202202); Zhejiang Province Leading Geese Plan (2025C04013); Zhejiang Provincial Traditional Chinese Medicine Science and Technology Program (Grant No. 2017ZZ012); Zhejiang Provincial Medical and Health Science and Technology Project (2022KY355 &2024KY402) and Fundamental Research Funds for the Central Universities (2022ZFJH003).
Authors
- Hao Xu (ORCID: https://orcid.org/0000-0001-5690-367X)
- Junfei Zhu
- Wei Yang (ORCID: https://orcid.org/0000-0002-3591-2195)
- Ruishan Liu
- Xiaojing Liu
- Tian Hu
- Zhencang Zheng
- Beiwen Zheng (ORCID: https://orcid.org/0000-0002-7690-372X)
- Lu Gong (ORCID: https://orcid.org/0000-0002-7265-3831)
- J. Shen (ORCID: https://orcid.org/0000-0001-6316-1168)
- Haowei Ye
- Kun Wang (ORCID: https://orcid.org/0009-0006-7995-3796)
Institutions
- Zhejiang Chinese Medical University (CN)
- Taizhou Central Hospital (CN)
- Jinan Infectious Disease Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- First Affiliated Hospital Zhejiang University (CN)
- State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
- Zhejiang University (CN)
Publication Details
- Journal
- EBioMedicine
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1016/j.ebiom.2025.105979
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.18