Trends in baseline HbA1c and body-mass index in randomised trials of people with type 1 diabetes from 1993 to 2025: an IMI2 SOPHIA systematic review and meta-analysis
The Stratification of Obesity Phenotypes to Optimize Future Obesity Therapy (SOPHIA) project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No. 875534, supported by the European Union's Horizon 2020 research and innovation program and EFPIA, with additional support from T1D Exchange, Breakthrough T1D (former JDRF), and Obesity Action Coalition.
Authors
- Margaretha M. Visser (ORCID: https://orcid.org/0000-0003-0216-4028)
- Carel Wynand le Roux (ORCID: https://orcid.org/0000-0001-5521-5445)
- Nele Steenackers (ORCID: https://orcid.org/0000-0003-4611-4962)
- Ebaa Al‐Ozairi (ORCID: https://orcid.org/0000-0001-5006-4369)
- Jonathan Rosen (ORCID: https://orcid.org/0000-0002-0670-8806)
- Carmen Hurtado del Pozo (ORCID: https://orcid.org/0000-0003-4379-0041)
- Yenny Leal (ORCID: https://orcid.org/0000-0003-1926-1844)
- Ann Mertens (ORCID: https://orcid.org/0000-0002-1649-4311)
- Bart Van der Schueren (ORCID: https://orcid.org/0000-0003-4754-784X)
- José Manuel Fernández‐Real (ORCID: https://orcid.org/0000-0002-7442-9323)
- Laura Gallardo‐Nuell
- Roman Vangoitsenhoven (ORCID: https://orcid.org/0000-0003-3523-669X)
- Chantal Mathieu (ORCID: https://orcid.org/0000-0002-6099-2406)
- Sofía Pazmiño Lucio
- Amar D E van Laar (ORCID: https://orcid.org/0000-0003-1289-0955)
Institutions
- University College Dublin (IE)
- University of Ulster (GB)
- Universitat de Girona (ES)
- Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (ES)
- Maastricht University (NL)
- Breakthrough (US)
- Institut d'Investigació Biomèdica de Girona (ES)
- Hospital Universitari de Girona Doctor Josep Trueta (ES)
- Dasman Diabetes Institute (KW)
- KU Leuven (BE)
Publication Details
- Journal
- EClinicalMedicine
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1016/j.eclinm.2025.103589
- Primary Topic
- Diabetes Management and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Federation of Pharmaceutical Industries and Associations
- European Commission